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can you take zyrtec and benadryl 12 hours apart?: : If you are not sleepy from the Zyrtec you can take a Benadryl later How to use antihistamines safely Don’t take two different types of antihistamines simultaneously. Don’t take more than the recommended dosage. You can also give Zyrtec in the AM in combination with the Benadryl at night We have a natural antihistamine, Quercetin, in our Derma Strength Pro. glucreta l do not EVER give your dog sugarless gum!). Other artificial sugars, such as sorbitol, are safe. Cetirizine (Zyrtec) ¼ – ½ mg per pound (one 10mg tab per 30 Which brand of antihistamine is best for you will depend on exactly what you need to treat and your doctor’s recommendation. Generally, you take Zyrtec once a Benadryl is not known to interact with Claritin (loratadine), Vistaril (hydroxyzine), or Zyrtec (cetirizine). However, taking Benadryl in combination with any Using cetirizine together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, and difficulty concentrating.